GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2243480 | 1 | rs431318 | chr7:65511597 | CCT6P1 | chr7:65216092-65228661:+ | 0.4 | 6.41 | 3.43E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs431318 | chr7:65511597 | CRCP | chr7:65579805-65619551:+ | -0.28 | -4.3 | 2.07E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs431318 | chr7:65511597 | RABGEF1 | chr7:66093890-66276446:+ | 0.57 | 7.06 | 5.74E-12 | Diabetic kidney disease |
| THCA | cis | rs2262909 | 1 | rs431328 | chr19:22222236 | ZNF257 | chr19:22235266-22273901:+ | 0.31 | 6.35 | 5.0E-10 | Chagas cardiomyopathy in Tripanosoma cruzi seropositivity |
| THCA | cis | rs7216064 | 1 | rs4318247 | chr17:65882172 | C17orf58 | chr17:65987218-65989765:- | 0.2 | 3.98 | 7.9E-5 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |
| THCA | cis | rs10461617 | 1 | rs43184 | chr5:56141777 | C5orf35 | chr5:56205103-56213010:+ | 1 | 22.99 | 2.46E-79 | Type 2 diabetes |
| THCA | cis | rs910316 | 1 | rs4322591 | chr14:75600697 | EIF2B2 | chr14:75469612-75476292:+ | 0.19 | 5.12 | 4.49E-7 | Height |
| THCA | cis | rs910316 | 1 | rs4322591 | chr14:75600697 | MLH3 | chr14:75480467-75518235:- | 0.3 | 8.98 | 6.21E-18 | Height |
| THCA | cis | rs910316 | 1 | rs4322591 | chr14:75600697 | RPS6KL1 | chr14:75372347-75389958:- | 0.32 | 6.87 | 1.95E-11 | Height |
| THCA | cis | rs7818688 | 1 | rs4323442 | chr8:96022986 | C8orf38 | chr8:95908040-96088396:+ | -0.25 | -4.3 | 2.03E-5 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| THCA | cis | rs881375 | 1 | rs4323544 | chr9:123647377 | LOC253039 | chr9:123605320-123616644:+ | -0.5 | -9.21 | 1.01E-18 | Rheumatoid arthritis |
| THCA | cis | rs881375 | 1 | rs4323544 | chr9:123647377 | PSMD5 | chr9:123578334-123605206:- | -0.27 | -5.21 | 2.79E-7 | Rheumatoid arthritis |
| THCA | cis | rs726288 | 1 | rs4325265 | chr10:81733655 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs10862219 | 1 | rs4326865 | chr12:81458579 | ACSS3 | chr12:81471809-81649582:+ | 0.22 | 4.67 | 4.01E-6 | Neuroticism |
| THCA | cis | rs9902453 | 1 | rs4328498 | chr17:28344276 | ANKRD13B | chr17:27916801-27941778:+ | -0.37 | -9.08 | 2.9E-18 | Coffee consumption (cups per day) |